Representatives from iNova Pharma Philippines Inc. (makers of Difflam-C gargle) together with Dr. Jennifer Nailes, MD, and Dr. Roberto Salvino, MD, the doctors who spearheaded the recent in-vivo study done by the UERM Memorial Medical Center Research team on the effectivity of the Difflam-C gargle against COVID 19-related throat pain, recently held a media roundtable to reveal their study’s findings.
(L-R) Michelle dela Cruz, Marketing Manager of iNova Pharma Philippines Inc., Ria Enriquez, Difflam Product Manager; Dr. Jennifer Nailes, vice president for research at University of the East Ramon Magsaysay Memorial Medical Center Inc, Dr. Roberto Salvino, Medical Director, iNova Pharma Philippines Inc., and Eric Yuson, Associate Medical Affairs Manager of iNova.
Difflam-C® is a locally-available antiseptic gargle
solution. It significantly alleviates the so-called COVID-19 Sore Throat – the
most common symptom and tell-tale sign of people diagnosed with COVID-19.
The in-vivo study focused on
establishing whether the combination of Benzydamine HCl and Chlorhexidine
gluconate in Difflam-C® are effective in a real-world setting and was
conducted on 219 COVID-19 patients from November 2021 until February 2022. This
combination of active ingredients found in Difflam-C® solution have been
gaining popularity in the Philippines particularly among doctors and healthcare
professionals, with the synergistic action of its anti-inflammatory, analgesic,
anesthetic, and antiseptic properties in relieving sore throat, as
well as other symptoms of throat and mouth infections.
Clinically-tested
Efficacy in COVID-19 Patients
Lead investigators of the study have
found that Difflam-C® significantly relieves the COVID-19 patients’ sore throat
and alleviated throat discomfort associated with difficulty and/or pain in
swallowing. Results also show that it helps shorten the duration of the said
condition of COVID-19 patients, with the VAS scores of participants
significantly decreased during course of treatment with Difflam-C®.
“At specified
time intervals, median VAS scores showed a decreasing trend from baseline until
after 12 hours of Day 1 and is significantly different from baseline values
(p<0.001). There were some participants whose sore throat pain were relieved
within 30 minutes of first use of the solution which persisted even until after
12 hours,” said lead investigator Dr.
Jennifer M. Nailes, MD, MSPH, Vice-President for Research of the University
of the East Ramon Magsaysay Memorial Medical Center, Inc.
Gargle Against COVID-19 Sore Throat
“There was a noticeable shortening of the course of the sore throat in the study subjects, with their use of Difflam-C® during treatment. This gargle solution could be viewed as an effective treatment for patients with odynophagia (painful swallowing) or dysphagia (difficulty swallowing), conditions associated with severe sore throat among COVID-19 patients,” said Dr. Nailes.
Though yet to be published by Acta Medica Philippina, a peer-reviewed general medical and health science journal, these results are extremely encouraging and present a positive step in addressing the COVID-19 sore throat, using a widely available medicated gargle solution such as Difflam-C® in the study.
As cases rise and new Omicron variants are discovered, the results of this study could be valuable information in making the public more aware of clinically tested remedies to help address key symptoms like the COVID-19 sore throat. While Benzydamine HCl + Chlorhexidine gluconate (Difflam-C®) could be an effective treatment for COVID-19 sore throat, getting vaccinated with boosters, the observance of standard health protocols, and maintaining a healthy lifestyle are the current mainstays for the prevention of COVID-19 infection.
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